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KMID : 1040020180090010001
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International Journal of Pain
2018 Volume.9 No. 1 p.1 ~ p.6
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Skin Biopsy and Small Fiber Neuropathy
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Suh Bum-Chun
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Abstract
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According to International Association for the Study of Pain (IASP), the definition of neuropathic pain is pain that arises as a direct consequence of a lesion or diseases affecting the somatosensory system. There are various tools to evaluate the peripheral nervous system. Traditionally, the most popular and reliable method for evaluation of peripheral nerve is the nerve conduction study. However, it can only estimate the integrity of fast-conducting large diameter peripheral nerve, so it has fundamental limitation of evaluation as a tool slow-conducting small diameter nerve that is responsible for pain sensation. With quantitative sensory testing (QST), skin biopsy for intraepidermal nerve fiber density (IENFD) is the gold standard method for evaluating small fiber neuropathy. This review would like to include an introduction to skin biopsy and its application to peripheral neuropathy.
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KEYWORD
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biopsy, immunohistochemistry, small fiber neuropathy, pain, UCHL 1 protein
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